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Label Urban Music Club Genres Hip Hop Track list References External links Cali y el Dandee on Facebook Category:2012 albumsHypoxia upregulates C-peptide in pancreatic beta-cells by modulating the JAK/STAT3 pathway. Hypoxia-induced diabetes and abnormal glucose metabolism are common in patients with end-stage renal disease. Hypoxia-inducible factor (HIF)-1alpha is a master regulator of cellular response to hypoxia. The aim of this study is to determine whether C-peptide, a marker of beta-cell function, is regulated by HIF-1alpha under hypoxia. beta-cell-specific HIF-1alpha transgenic mice were generated to examine the direct effect of HIF-1alpha on C-peptide expression. Studies of primary cultured islets revealed that islet-specific overexpression of HIF-1alpha increased mRNA and protein levels of C-peptide. In contrast, HIF-1alpha knockout islets exhibited reduced C-peptide expression. In addition, HIF-1alpha overexpression enhanced phosphorylation of STAT3 and activation of its target gene BCL2 under hypoxia, and the increase in C-peptide expression was abrogated by a pharmacological inhibitor of JAK/STAT3 signaling. Taken together, these results indicate that C-peptide expression is upregulated by HIF-1alpha under hypoxia through the JAK/STAT3 signaling pathway./** * @fileoverview Detect file type from file extension * @author NHN FE Development Lab */ 'use strict'; let reader = require('../reader'); module.exports = class { /** * detectFileType * @return {Promise} */ static detectFileType(filepath) { return new Promise((resolve, reject) => { reader.load(filepath, (err, module) => { if (err) { return reject(err); } if (module be359ba680

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